Interviews: There will be a two-stage process comprising of an online interview and an in-person interview.

In-person interview: 3rd December 2026

Closing date for applications: 15th November 2026

The UK Dementia Research Institute (UK DRI) is a globally leading multidisciplinary research institute with a community of c. 1000 researchers investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

Research produces papers, datasets and promising ideas, but the connections between them are difficult to maintain. A finding may depend on an untested assumption. Two apparent contradictions may concern different experimental systems. Several labs may be blocked by the same missing capability. Important negative results and developing work may never become visible outside the team that produced them.

Help UK DRI understand what is known, where the evidence disagrees and what work could make the biggest difference next. You can learn more about our ambitions here.

You will develop the strategy and build software that makes these questions easier to investigate and act on. Starting with a focused Alzheimer’s disease research question, you will help scientists create and maintain an inspectable map of claims, evidence, disagreements, capabilities and possible routes towards a meaningful outcome. Over time, that work should connect published literature with selected, authorised unpublished research and the knowledge held across UK DRI laboratories.

We are looking for a technical leader who thinks big and cares about how science establishes knowledge and how institutions help people learn and work together. You might already be interested in discourse graphs, claims and evidence, outcome graphs, reproducibility, open science or new ways of organising research. You might have encountered the same problems while building search tools, scientific data systems or collaborative software. We value the ability to turn that curiosity and ability to think big into useful working systems.

You will be a founding member of the UK DRI AI initiative, working as a peer with an engineer building Lab Brains and scientific workflows. Together, you will connect what laboratories learn and influence what the institute can understand and do.

What you'll build

• A practical representation of scientific questions, scoped claims, supporting and opposing evidence, sources, methods and uncertainty. Keep exact source links, versions and the distinction between proposed and reviewed interpretations.

• Ingestion, extraction, reconciliation and update pipelines for an agreed scientific corpus, with interfaces that make it easy for researchers to inspect, qualify and correct the results.

• Views that reveal where findings agree, genuinely disagree or cannot yet be compared, without treating missing evidence as evidence against a claim.

• A first Alzheimer outcome map: work with scientists to describe what must become possible for a selected outcome, the alternative routes, unresolved assumptions, missing capabilities and next decisions.

• Connections between that map and reviewed institutional capabilities, datasets and developing research, making potential collaborations or shared bottlenecks specific enough for people to evaluate.

• Decision dossiers and feedback tools that record what was considered, what an accountable owner chose, what was tried and how subsequent evidence changed the picture.

Choose data models, search and graph technologies according to the task. Learn from communities such as Discourse Graphs and existing outcome-planning approaches, compare available tools and publish or contribute reusable work where permissions and licensing allow.

How you will work

Build with scientists and methodologists, combining software development with focused scientific review. Help reviewers make disagreement explicit and productive. Design the workflow so that maintaining the shared account requires less effort than reconstructing it repeatedly.

Lead on system evaluation against ordinary search and structured evidence review on the same questions and sources. Measure evidence quality, scope errors, review effort, correction and whether the work improves a real decision or hand-off. Preserve failed ideas, alternative interpretations and justified no-action decisions.

Reproducibility is central: a reader should be able to inspect the source and analysis behind a claim, understand its limitations and see what changed. Laboratory owners retain control over what is shared. Scientific and programme decisions remain with accountable people, supported by the software you build.

Influence how senior management embraces AI across the Institute to deliver its mission faster.

What you bring

• Strong programming ability and evidence of delivering useful software, with the ability to learn the languages and tools needed by the codebase.

• Sound engineering practice: Git with GitHub or equivalent, code review, tests, continuous integration, documentation, packaging, dependency management and maintainable releases.

• Experience modelling and integrating complex information, for example in scientific data systems, search, evidence synthesis, collaborative knowledge tools or research software.

• The ability to reason carefully about evidence, ambiguity, provenance and changing interpretations, and translate that reasoning into usable software.

• Practical experience applying and evaluating language models or related information-extraction/retrieval methods, with a clear account of their failure modes.

• Curiosity about how scientific communities establish knowledge and coordinate work, and a commitment to reproducibility, open collaboration and constructive disagreement.

• Enthusiasm and ability to influence how an organisation can drive change through technology adoption.

• The ability to work autonomously and lead: set priorities, make and justify technical and strategic decisions, bring others with you and take ownership of outcomes.

Experience with knowledge graphs, ontologies, discourse graphs, evidence synthesis, interface design, biomedical research or open-source scientific software would be valuable. Prior expertise in a particular graph database, a particular programming language or Alzheimer's research is not required. Scientific judgement will be developed with domain experts. We welcome varied professional and educational paths; no particular degree or PhD is required where equivalent capability can be demonstrated.

Early priorities

First month: agree one scientific question and intended outcome with named reviewers; define a small source corpus and a baseline; build an inspectable first representation of evidence and uncertainty.

By three months: deliver a reviewed claim-and-evidence view and an initial outcome map that scientists can correct, including an explicit disagreement or unresolved assumption and a documented next decision.

By six months: connect the map to an approved lab or institutional workflow, test a proposed capability hand-off or scientific follow-up, and show what the system adds beyond simpler retrieval and manual review.

By twelve months: maintain the scoped resource as evidence changes, demonstrate a documented decision/action/result feedback loop, and deliver an implementation strategy for reusable software, evaluation methods and present a justified plan for further field coverage to senior management.

What we offer

We believe in rewarding our team with more than just a competitive base salary an opportunity to make a difference. Here’s what you can look forward to:

Work-Life Balance

• Generous holiday allowance: 27 days of annual leave (plus UK Bank Holidays) to recharge and explore.

• Business closure days: Enjoy up to 6 additional days off each year.

Health & Wellbeing

• Private medical cover: Single medical insurance to support your health and peace of mind.

• Group Life Assurance: Protection for your loved ones with coverage up to 4x your base salary.

• Income Protection & Critical Illness Cover: Financial security when you need it most.

• Employee Assistance Programme: Confidential support for your mental and emotional wellbeing.

Family-Friendly Support

• Enhanced maternity, paternity, neonatal and adoption pay: Because family matters.

Financial Perks

• Season Ticket Loan: Save on your commute with an interest-free loan.

• Generous pension scheme: Contribute 6.1% as an employee, with an employer contribution of 15.9% helping you build a secure future.

Plus

• Voluntary benefits programme: Access a wide range of discounts and perks tailored to your lifestyle.

• Hybrid working: We embrace a hybrid working model, with the majority of your time spent in our collaborative modern office environment in London. We offer the flexibility to work remotely for up to 1-2 days per week.

To apply

Please submit your CV and covering letter detailing why you wish to join the UK DRI, your availability, and your experience for this role.

No agencies please.  We are unable to provide sponsorship.

By applying to this role, you understand and agree that your information will be shared within the UK DRI People & Culture team and/or any team members who will be part of the hiring process.

UK DRI is committed to equal opportunities.

The UK DRI embraces diversity, inclusion and accessibility for all of our people. We are committed to building a diverse organisation that represents the communities we serve and ensuring inclusion in everything we do. This means ensuring our recruitment processes are barrier-free and as inclusive as possible to everyone. We will make adjustments for people who have a disability or long-term condition.